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Keywords:

  • cyclization;
  • fluorine;
  • gold;
  • homogeneous catalysis;
  • ynones
Thumbnail image of graphical abstract

Gold standard: AuCl was found to be the only suitable catalyst for the 6-endo-dig ring closure of hydroxylated difluorinated ynones (see scheme), a class of substrates that displays low reactivity owing to the presence of the gem-difluoro group. For the first time, a gold catalyst is used in combination with an electrophilic fluorinating reagent.