We thank the NIH (National Institute of General Medical Sciences) and Merck Research Laboratories, each for partial support.
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Communication
Functional Analysis of an Aspartate-Based Epoxidation Catalyst with Amide-to-Alkene Peptidomimetic Catalyst Analogues†
Article first published online: 22 JUL 2008
DOI: 10.1002/anie.200802223
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Jakobsche, C., Peris, G. and Miller, S. (2008), Functional Analysis of an Aspartate-Based Epoxidation Catalyst with Amide-to-Alkene Peptidomimetic Catalyst Analogues. Angewandte Chemie International Edition, 47: 6707–6711. doi: 10.1002/anie.200802223
- †
Publication History
- Issue published online: 11 AUG 2008
- Article first published online: 22 JUL 2008
- Manuscript Received: 12 MAY 2008
Funded by
- NIH
- Merck Research Laboratories
Keywords:
- asymmetric catalysis;
- epoxidation;
- fluorine;
- olefin isostere;
- peptides;
- peptidomimetic
Graphical Abstract
Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure-dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action.