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Self-Assembly of a Cavitand-Based Capsule by Dynamic Boronic Ester Formation


  • This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science, Sports, Culture, and Technology (Japan) (No. 17350067).


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Be my guest: Two molecules of a cavitand tetraboronic acid and four molecules of a bis(catechol) linker quantitatively assemble into a capsule (see picture for two views), with highly selective guest-recognition, by dynamic boronic ester formation. The on/off control of capsule formation with guest encapsulation is achieved by removal/addition of methanol.