Hollow Manganese Oxide Nanoparticles as Multifunctional Agents for Magnetic Resonance Imaging and Drug Delivery


  • This work was supported by a Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2007-331-C00145). J.H.L. is supported by the Center for Biological Modulators of the 21st Century Frontier R&D Program (CBM31-B3002-00-00-00). We thank Prof. Jungahn Kim at Kyung Hee University for his kind donation of doxorubicin.


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MRI jack-o'-lanterns? Hollow manganese oxide nanoparticles (HMON) show greatly improved relaxivities and drug-loading capacities compared to those with solid interiors (WMON). Their efficient cellular uptake demonstrates their potential as a bifunctional medical system that combines diagnostic imaging and targeted therapy.