This research was supported by the Netherlands Proteomics Centre and the NIAMS Intramural Research Program of the NIH.
Stability and Shape of Hepatitis B Virus Capsids In Vacuo†
Article first published online: 18 JUL 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 33, pages 6247–6251, August 4, 2008
How to Cite
Uetrecht, C., Versluis, C., Watts, Norman R., Wingfield, Paul T., Steven, Alasdair C. and Heck, Albert J. R. (2008), Stability and Shape of Hepatitis B Virus Capsids In Vacuo. Angew. Chem. Int. Ed., 47: 6247–6251. doi: 10.1002/anie.200802410
- Issue published online: 29 JUL 2008
- Article first published online: 18 JUL 2008
- Manuscript Received: 23 MAY 2008
- analytical methods;
- conformational analysis;
- ion mobility;
- mass spectrometry;
Viruses at a glance: Ion mobility mass spectrometry allows the identification and differentiation of states in a viral assembly not only by mass but also by conformation. This approach has been used to obtain a biophysical characterization of the hepatitis B virus capsids, and has shown that of its two distinct icosahedral geometries, the spherical capsid structure is preserved in vacuo (see picture).