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Keywords:

  • analytical methods;
  • conformational analysis;
  • ion mobility;
  • mass spectrometry;
  • viruses
Thumbnail image of graphical abstract

Viruses at a glance: Ion mobility mass spectrometry allows the identification and differentiation of states in a viral assembly not only by mass but also by conformation. This approach has been used to obtain a biophysical characterization of the hepatitis B virus capsids, and has shown that of its two distinct icosahedral geometries, the spherical capsid structure is preserved in vacuo (see picture).