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New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan

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  • This work was supported by the Deutsche Forschungsgemeinschaft (PE-348/17-2) and the Arbeitsgemeinschaft industrieller Forschungsvereinigungen “Otto von Guericke” e.V. (14262 BG/1).

Abstract

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It takes two: Both a lysine and a glutamate residue in the active site of tryptophan halogenase are essential for its chlorination activity. A mechanism for the regioselective enzymatic chlorination of tryptophan involving both amino acids is suggested (see scheme).

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