These authors contributed equally to this work.
Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery†
Article first published online: 25 AUG 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 44, pages 8438–8441, October 20, 2008
How to Cite
Kim, J., Kim, H., Lee, N., Kim, T., Kim, H., Yu, T., Song, I., Moon, W. and Hyeon, T. (2008), Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery. Angew. Chem. Int. Ed., 47: 8438–8441. doi: 10.1002/anie.200802469
T.H. acknowledges financial support by the Korean Ministry of Education, Science and Technology through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). This study was supported in part by a grant from the Innovative Research Institute for Cell Therapy, Republic of Korea (A062260).
- Issue published online: 15 OCT 2008
- Article first published online: 25 AUG 2008
- Manuscript Revised: 17 JUL 2008
- Manuscript Received: 27 MAY 2008
- Korea Science and Engineering Foundation (KOSEF)
- Innovative Research Institute for Cell Therapy, Republic of Korea. Grant Number: A062260
- drug delivery;
- magnetic resonance;
- mesoporous materials;
Magnetic, fluorescent core–shell nanoparticles consist of a single Fe3O4 nanocrystal core and a dye-doped mesoporous silica shell with a poly(ethylene glycol) coating (see picture of TEM images and schematic depictions). These nanoparticles can be used as magnetic resonance and fluorescence imaging agents, and as drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis and therapy.