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The Emergence of Thiol–Ene Coupling as a Click Process for Materials and Bioorganic Chemistry


  • I thank my colleague Prof. A. Marra and postdoctoral fellow Dr. M. Fiore for valuable help with literature searches.


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The century-old thiol–ene radical reaction is now being recognized among the ranks of other click-type reactions (see scheme). Recent applications in dendrimer and glycopeptide syntheses demonstrate the efficiency of this process for the assembly of complex molecular systems.