Get access

Organocatalytic Asymmetric Domino Reactions: A Cascade Consisting of a Michael Addition and an Aldehyde α-Alkylation


  • This work was supported by the Deutsche Forschungsgemeinschaft (priority program Organocatalysis) and the Fonds der Chemischen Industrie.


original image

A direct approach to cyclic γ-nitroaldehydes with an all-carbon-substituted quaternary stereocenter is provided by a novel organocatalytic diastereo- and enantioselective cascade consisting of a Michael addition and an aldehyde α-alkylation (see scheme). The corresponding γ-amino acids are available in two steps.

Get access to the full text of this article