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Organocatalytic Asymmetric Domino Reactions: A Cascade Consisting of a Michael Addition and an Aldehyde α-Alkylation

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  • This work was supported by the Deutsche Forschungsgemeinschaft (priority program Organocatalysis) and the Fonds der Chemischen Industrie.

Abstract

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A direct approach to cyclic γ-nitroaldehydes with an all-carbon-substituted quaternary stereocenter is provided by a novel organocatalytic diastereo- and enantioselective cascade consisting of a Michael addition and an aldehyde α-alkylation (see scheme). The corresponding γ-amino acids are available in two steps.

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