We are grateful to the CNRS and the region of Languedoc Roussillon for a PhD grant and financial support.
A Very Simple Copper-Catalyzed Synthesis of Anilines by Employing Aqueous Ammonia†
Article first published online: 1 OCT 2008
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 2, pages 337–339, January 2, 2009
How to Cite
Xia, N. and Taillefer, M. (2009), A Very Simple Copper-Catalyzed Synthesis of Anilines by Employing Aqueous Ammonia. Angew. Chem. Int. Ed., 48: 337–339. doi: 10.1002/anie.200802569
- Issue published online: 22 DEC 2008
- Article first published online: 1 OCT 2008
- Manuscript Received: 2 JUN 2008
- homogeneous catalysis
Phasing up to matters: The use of aqueous ammonia in a biphasic system with a copper catalyst and diketone supporting ligands allows the catalytic amination of both activated and unactivated aryl and heteroaryl iodides and bromides under very mild conditions (see scheme; R=electron-donating or -withdrawing group; acac=acetylacetonate).