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A Very Simple Copper-Catalyzed Synthesis of Anilines by Employing Aqueous Ammonia


  • We are grateful to the CNRS and the region of Languedoc Roussillon for a PhD grant and financial support.


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Phasing up to matters: The use of aqueous ammonia in a biphasic system with a copper catalyst and diketone supporting ligands allows the catalytic amination of both activated and unactivated aryl and heteroaryl iodides and bromides under very mild conditions (see scheme; R=electron-donating or -withdrawing group; acac=acetylacetonate).

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