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Gold(I)-Catalyzed Tandem Reactions Initiated by 1,2-Indole Migrations


  • We gratefully thank Ministerio de Educación y Ciencia (MEC) and FEDER (CTQ2007-61436/BQU), and Junta de Castilla y León (BU012A06) for financial support. D.M. thanks MEC for a predoctoral FPU fellowship. F.R. is grateful to MEC and Fondo Social Europeo for a Ramón y Cajal contract. We also thank Dr. Jacinto Delgado (SCAI-Universidad de Burgos) for help with the X-ray structure determination.


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Take your pick! Indene-containing indole scaffolds have been catalytically prepared from C3-propargylated indoles by tandem reactions involving an initial 1,2-indole migration. This unprecedented process generates a gold carbene complex and proceeds through either a formal C[BOND]H insertion or a Nazarov cyclization (see scheme).

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