Support has been provided by the NIH (National Institute of General Medical Sciences, R01-GM62871), Merck Research Laboratories, and Novartis.
Nickel-Catalyzed Negishi Cross-Couplings of Secondary Nucleophiles with Secondary Propargylic Electrophiles at Room Temperature†
Article first published online: 29 OCT 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 48, pages 9334–9336, November 17, 2008
How to Cite
Smith, Sean W. and Fu, Gregory C. (2008), Nickel-Catalyzed Negishi Cross-Couplings of Secondary Nucleophiles with Secondary Propargylic Electrophiles at Room Temperature. Angew. Chem. Int. Ed., 47: 9334–9336. doi: 10.1002/anie.200802784
- Issue published online: 12 NOV 2008
- Article first published online: 29 OCT 2008
- Manuscript Revised: 13 JUL 2008
- Manuscript Received: 12 JUN 2008
- NIH (National Institute of General Medical Sciences. Grant Number: R01-GM62871
- Merck Research Laboratories
- homogeneous catalysis;
Mild thing: The first nickel-based catalysts for cross-couplings of secondary organometallic nucleophiles with secondary alkyl electrophiles have been developed. Thus, Negishi reactions proceed under mild conditions (at room temperature with no basic activators) in the presence of NiCl2⋅glyme and a tridentate ligand (see scheme).