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Keywords:

  • alkynes;
  • cross-coupling;
  • homogeneous catalysis;
  • nickel;
  • zinc
Thumbnail image of graphical abstract

Mild thing: The first nickel-based catalysts for cross-couplings of secondary organometallic nucleophiles with secondary alkyl electrophiles have been developed. Thus, Negishi reactions proceed under mild conditions (at room temperature with no basic activators) in the presence of NiCl2⋅glyme and a tridentate ligand (see scheme).