Support has been provided by the NIH (National Institute of General Medical Sciences, R01-GM62871), Merck Research Laboratories, and Novartis.
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Communication
Nickel-Catalyzed Negishi Cross-Couplings of Secondary Nucleophiles with Secondary Propargylic Electrophiles at Room Temperature†
Article first published online: 29 OCT 2008
DOI: 10.1002/anie.200802784
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 47, Issue 48, pages 9334–9336, November 17, 2008
Additional Information
How to Cite
Smith, Sean W. and Fu, Gregory C. (2008), Nickel-Catalyzed Negishi Cross-Couplings of Secondary Nucleophiles with Secondary Propargylic Electrophiles at Room Temperature. Angew. Chem. Int. Ed., 47: 9334–9336. doi: 10.1002/anie.200802784
- †
Publication History
- Issue published online: 12 NOV 2008
- Article first published online: 29 OCT 2008
- Manuscript Revised: 13 JUL 2008
- Manuscript Received: 12 JUN 2008
Funded by
- NIH (National Institute of General Medical Sciences. Grant Number: R01-GM62871
- Merck Research Laboratories
- Novartis
Keywords:
- alkynes;
- cross-coupling;
- homogeneous catalysis;
- nickel;
- zinc
Mild thing: The first nickel-based catalysts for cross-couplings of secondary organometallic nucleophiles with secondary alkyl electrophiles have been developed. Thus, Negishi reactions proceed under mild conditions (at room temperature with no basic activators) in the presence of NiCl2⋅glyme and a tridentate ligand (see scheme).