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Nickel-Catalyzed Negishi Cross-Couplings of Secondary Nucleophiles with Secondary Propargylic Electrophiles at Room Temperature


  • Support has been provided by the NIH (National Institute of General Medical Sciences, R01-GM62871), Merck Research Laboratories, and Novartis.


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Mild thing: The first nickel-based catalysts for cross-couplings of secondary organometallic nucleophiles with secondary alkyl electrophiles have been developed. Thus, Negishi reactions proceed under mild conditions (at room temperature with no basic activators) in the presence of NiCl2⋅glyme and a tridentate ligand (see scheme).