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Cryo Electron Tomography Reveals Confined Complex Morphologies of Tripeptide-Containing Amphiphilic Double-Comb Diblock Copolymers

Authors

  • Alison L. Parry Dr.,

    1. Functional Materials Group, Chemical Laboratory, School of Physical Sciences, University of Kent at Canterbury, Canterbury, Kent, CT2 7NR (UK), Fax: (+44) 1227-827-558
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  • Paul H. H. Bomans,

    1. Laboratory of Materials and Interface Chemistry and Soft Matter Cryo-TEM Research Unit, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven (The Netherlands)
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  • Simon J. Holder Dr.,

    1. Functional Materials Group, Chemical Laboratory, School of Physical Sciences, University of Kent at Canterbury, Canterbury, Kent, CT2 7NR (UK), Fax: (+44) 1227-827-558
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  • Nico A. J. M. Sommerdijk Dr.,

    1. Laboratory of Materials and Interface Chemistry and Soft Matter Cryo-TEM Research Unit, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven (The Netherlands)
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  • Stefano C. G. Biagini Dr.

    1. Functional Materials Group, Chemical Laboratory, School of Physical Sciences, University of Kent at Canterbury, Canterbury, Kent, CT2 7NR (UK), Fax: (+44) 1227-827-558
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  • We thank Dr. K. Lyakhova for valuable discussions.

Abstract

original image

Sequence sets structure: Amphiphilic norbornene-based double-comb diblock polymers with peptide and oligo(ethylene oxide) side chains aggregate in water to form unprecedented complex morphologies depending on the amino acid sequence of the peptide. The internal structures of the aggregates observed by cryo electron tomography show densely folded and highly branched wormlike micelles (left) and spherical aggregates with a bicontinuous architecture (right).

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