One- and Two-Dimensional NMR Spectroscopy with a Magnetic-Resonance Force Microscope


  • Scientific advice by Jacco van Beek, René Verel, and Urban Meier and financial support by the Schweizerischer Nationalfonds, the ETH Zurich, and the Kommission für Technologie und Innovation is acknowledged.


original image

At the micrometer scale: Chemical interactions at the atomic level have been characterized with localized spectroscopy by using magnetic-resonance force microscopy to locate slices of 2.0 μm thickness in a heterogeneous sample (see picture). To recover the chemical-shift information, the field gradient was temporarily switched off by removing its source mechanically. This technique allows high-resolution one- and two-dimensional NMR spectra to be recorded.