Coiled-Coil Lipopeptides Mimicking the Prehairpin Intermediate of Glycoprotein gp41



original image

A sheep in wolf's clothes? Mimicking the crucial conformational step in viral fusion promises to be an efficient method to detect potential antagonists of retroviral infection (see scheme). Reconstituted lipopeptides derived from the N peptides of the class I virus fusion protein of SIV serve as receptors for potential inhibitors that function like the C peptides of the virus protein.