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Efficient Catalytic System for the Selective Production of 5-Hydroxymethylfurfural from Glucose and Fructose


  • This work was supported by the Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore).


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A sweet conversion! A NHC–Cr/ionic liquid system has achieved excellent efficiency and the highest 5-hydroxymethylfurfural (1; see scheme; NHC=N-heterocyclic carbene) yields reported thus far for both fructose and glucose feedstocks. The catalyst and ionic liquid are tolerant of high substrate loading and can be recycled after extraction of the product.