Selective Synthesis of Primary Amines Directly from Alcohols and Ammonia


  • This research was supported by the Israel Science Foundation and the Kimmel Center for Molecular Design. C.G. is the recipient of a Dean of Faculties Postdoctoral Fellowship. D.M. is the Israel Matz Professorial Chair of Organic Chemistry.


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Air stable and waterproof: Selective and efficient synthesis of primary amines directly from alcohols and ammonia is achieved under mild conditions (see scheme). The reaction is homogenously catalyzed by a novel air-stable ruthenium pincer complex and can proceed in toluene or even in the absence of solvent or “on water”.