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Bond- and Energy-Selective Carbon Abstraction from D-Ribose by Hyperthermal Nitrogen Ions

Authors

  • Zongwu Deng Dr.,

    1. Ion Reaction Laboratory, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada), Fax: (+1) 819-564-5442
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  • Ilko Bald Dr.,

    1. Ion Reaction Laboratory, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada), Fax: (+1) 819-564-5442
    2. Permanent address: Institut für Chemie – Physikalische und Theoretische Chemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany)
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  • Eugen Illenberger Prof. Dr.,

    1. Ion Reaction Laboratory, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada), Fax: (+1) 819-564-5442
    2. Permanent address: Institut für Chemie – Physikalische und Theoretische Chemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany)
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  • Michael A. Huels Prof. Dr.

    1. Ion Reaction Laboratory, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada), Fax: (+1) 819-564-5442
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  • This work is supported by NSERC of Canada, and the Canadian Space Agency. A NATO grant allowed staff travel to Sherbrooke (I.B.).

Abstract

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Stealing C: Scattering of hyperthermal nitrogen ions from a D-ribose film efficiently abstracts carbon from the molecule to form CN (see scheme). The reaction is strongly bond and energy selective for C5 of D-ribose in its pyranose form. The sugar moiety of the DNA/RNA backbone will thus be a vulnerable point for damage caused by reactive scattering of secondary atomic nitrogen ions produced by energetic heavy ions.

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