This research is supported by the Converging Technologies Project, Israel Science Foundation. We thank Shira Winograd for her help with the synthesis of the quantum dots.
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Communication
Biosensing and Probing of Intracellular Metabolic Pathways by NADH-Sensitive Quantum Dots†
Article first published online: 3 DEC 2008
DOI: 10.1002/anie.200803421
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Freeman, R., Gill, R., Shweky, I., Kotler, M., Banin, U. and Willner, I. (2009), Biosensing and Probing of Intracellular Metabolic Pathways by NADH-Sensitive Quantum Dots. Angewandte Chemie International Edition, 48: 309–313. doi: 10.1002/anie.200803421
- †
Publication History
- Issue published online: 22 DEC 2008
- Article first published online: 3 DEC 2008
- Manuscript Revised: 31 AUG 2008
- Manuscript Received: 15 JUL 2008
Funded by
- Israel Science Foundation
- Abstract
- Article
- References
- Cited By
Keywords:
- biosensors;
- enzymes;
- nanobiotechnology;
- nanoparticles;
- quantum dots
Graphical Abstract
On the blue Nile: NAD(P)H-sensitive Nile Blue functionalized CdSe/ZnS quantum dots have been developed for the optical sensing of biocatalytic processes involving NAD+-dependent enzymes and the screening of anticancer drugs by monitoring intracellular metabolism (see picture).