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Synthesis of Natural Product Inspired Compound Collections

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Abstract

Mimicking nature synthetically: The successful development of multistep stereoselective syntheses gives access to natural product inspired compound collections having carbo-, oxa-,and azacyclic scaffold structures which promise to provide sources for new reagents in medicinal chemistry and chemical biology research.

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Natural products, their derivatives, and their analogues are among the most important sources for new drug candidates and tools for chemical biology and medicinal chemistry research. Therefore, there is a need for the development of efficient synthesis methods which give access to natural product derived and inspired compound collections. To meet this challenge, the requirements of multistep stereoselective syntheses, and the logic and methodology of natural product total synthesis need to be translated and adapted to the methods and formats for the synthesis of compound collections. Recent developments in the synthesis of natural product inspired compound collections having carbocyclic and heterocyclic scaffolds highlight the fact that this goal can be successfully attained. The progress made has paved the way for the integration of natural product inspired compound collections into medicinal chemistry and chemical biology research.

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