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Communication
Straightforward and Reversible Photoregulation of Hybridization by Using a Photochromic Nucleoside
Article first published online: 10 OCT 2008
DOI: 10.1002/anie.200803496
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Ogasawara, S. and Maeda, M. (2008), Straightforward and Reversible Photoregulation of Hybridization by Using a Photochromic Nucleoside. Angew. Chem. Int. Ed., 47: 8839–8842. doi: 10.1002/anie.200803496
Publication History
- Issue published online: 28 OCT 2008
- Article first published online: 10 OCT 2008
- Manuscript Revised: 20 AUG 2008
- Manuscript Received: 18 JUL 2008
Keywords:
- DNA structures;
- nucleosides;
- photochemistry;
- photochromism
A light switch: A strategy for the photoregulation of hybridization by using the cis–trans photoisomerization of a photochromic nucleoside (PCN) is reported. This process enables the switch between duplexes and single strands in an extremely straightforward and reversible manner with light stimulation (see scheme), even at room temperature. Additionally, installation of PCNs into DNA had little influence on the B-form structure when the duplex was formed.