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Keywords:

  • carbohydrates;
  • enzymes;
  • glycosides;
  • glycosylation;
  • natural products
Thumbnail image of graphical abstract

A sweet library: Two variants (wild-type (WT) and a triple mutant) of glycosyltransferase (GT) OleD have been shown to catalyze glycosylation of over 70 substrates, formation of O-, S- and N-glycosidic bonds, and iterative glycosylation (see scheme). Identified substrates include nucleophiles not previously known to act in GT reactions and span numerous natural product and therapeutic drug classes.