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Enantioselective Induction of Helical Chirality in Cyclooctapyrroles by Metal-Complex Formation


  • This research was supported by a Grant-in-Aid for Scientific Research (No. 18550058) from the Ministry of Education, Culture, Sports, Science, and Technology (Japan). We are also grateful to the CREST program (Japan Science and Technology Agency) and the VBL project (Kobe University).


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Fixed chirality: The treatment of cyclooctapyrroles (see picture) with a metal source with optically active carboxylate or amine ligands leads to enantioselective metalation to give stereochemically stable helical mononuclear and dinuclear complexes without a chiral auxiliary. The helicity of the dicopper complex was determined by the simulation of the CD spectrum on the basis of X-ray crystallographic data.