This work was supported by the NIH (GM49216).
Ping-Pong Electron Transfer through DNA†
Article first published online: 16 OCT 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 47, pages 9067–9070, November 10, 2008
How to Cite
Elias, B., Genereux, Joseph C. and Barton, Jacqueline K. (2008), Ping-Pong Electron Transfer through DNA. Angew. Chem. Int. Ed., 47: 9067–9070. doi: 10.1002/anie.200803556
- Issue published online: 5 NOV 2008
- Article first published online: 16 OCT 2008
- Manuscript Received: 22 JUL 2008
- NIH. Grant Number: GM49216
- charge transport;
- DNA damage;
Either way: An IrIII complex strongly coupled to a DNA base stack can inject a hole or an electron in DNA upon irradiation (see picture). With strands containing the modified bases CPA and CPC/BrU, which serve as oxidative and reductive probes, respectively, photolysis of Ir–DNA conjugates leads to a “ping-pong” electron transfer, with both hole and electron migration.