Ping-Pong Electron Transfer through DNA


  • This work was supported by the NIH (GM49216).


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Either way: An IrIII complex strongly coupled to a DNA base stack can inject a hole or an electron in DNA upon irradiation (see picture). With strands containing the modified bases CPA and CPC/BrU, which serve as oxidative and reductive probes, respectively, photolysis of Ir–DNA conjugates leads to a “ping-pong” electron transfer, with both hole and electron migration.