We are grateful to the Fonds der Chemischen Industrie for financial support, and S.-M.L. thanks the Alexander von Humboldt Foundation for a postdoctoral fellowship. We also acknowledge Dr. C. Jaekel (BASF AG) for pointing out Refs. [5h] and .
Highly Enantioselective Synthesis of Optically Active Ketones by Iridium-Catalyzed Asymmetric Hydrogenation†
Article first published online: 15 OCT 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 46, pages 8920–8923, November 3, 2008
How to Cite
Lu, S.-M. and Bolm, C. (2008), Highly Enantioselective Synthesis of Optically Active Ketones by Iridium-Catalyzed Asymmetric Hydrogenation. Angew. Chem. Int. Ed., 47: 8920–8923. doi: 10.1002/anie.200803709
- Issue published online: 28 OCT 2008
- Article first published online: 15 OCT 2008
- Manuscript Received: 29 JUL 2008
- Fonds der Chemischen Industrie
- asymmetric synthesis;
Close to perfect enantioselectivity (up to 99 % ee, see scheme) is found for the formation of α-substituted ketones by the asymmetric hydrogenation of enones with an iridium–phosphinooxazoline catalyst. In an operationally simple process, both linear and cyclic substrates react well and afford the desired products in high yields. A wide variety of substituents are tolerated, thus making the method synthetically appealing.