We thank Dr. Moritz Biskup for valuable comments.
Highlights in Steroid Chemistry: Total Synthesis versus Semisynthesis†
Article first published online: 9 OCT 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 49, pages 9389–9391, November 24, 2008
How to Cite
Nising, Carl F. and Bräse, S. (2008), Highlights in Steroid Chemistry: Total Synthesis versus Semisynthesis. Angew. Chem. Int. Ed., 47: 9389–9391. doi: 10.1002/anie.200803720
- Issue published online: 20 NOV 2008
- Article first published online: 9 OCT 2008
- cortistatin A;
- natural products;
- total synthesis
Many routes to the destination: Cortistatins are steroids of marine origin of which cortistatin A has the highest antiangiogenetic action. Several total syntheses of this natural product have recently been achieved, based on biosynthesis, biomimetic synthesis, semisynthesis, and de novo synthesis, which are compared in this Highlight.