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Keywords:

  • cortistatin A;
  • natural products;
  • semisynthesis;
  • steroids;
  • total synthesis
Thumbnail image of graphical abstract

Many routes to the destination: Cortistatins are steroids of marine origin of which cortistatin A has the highest antiangiogenetic action. Several total syntheses of this natural product have recently been achieved, based on biosynthesis, biomimetic synthesis, semisynthesis, and de novo synthesis, which are compared in this Highlight.