Communication

Formal Asymmetric Biocatalytic Reductive Amination†

  1. Dominik Koszelewski Dr.1,
  2. Iván Lavandera Dr.1,
  3. Dorina Clay1,
  4. Georg M. Guebitz Prof.2,
  5. David Rozzell Dr.3,
  6. Wolfgang Kroutil Prof.1

Article first published online: 29 OCT 2008

DOI: 10.1002/anie.200803763

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 48, pages 9337–9340, November 17, 2008

Additional Information

How to Cite

Koszelewski, D., Lavandera, I., Clay, D., Guebitz, Georg M., Rozzell, D. and Kroutil, W. (2008), Formal Asymmetric Biocatalytic Reductive Amination. Angew. Chem. Int. Ed., 47: 9337–9340. doi: 10.1002/anie.200803763

Author Information

  1. 1

    Research Centre Applied Biocatalysis, c/o Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840

  2. 2

    Institute of Environmental Biotechnology, Research Centre Applied Biocatalysis, University of Technology, Petersgasse 12, 8010 Graz (Austria)

  3. 3

    Codexis, Inc., Redwood City, CA (USA)

  1. †

    Financial support by the FFG and the Province of Styria is gratefully acknowledged. Codexis is thanked for providing various enzymes.

Publication History

  1. Issue published online: 12 NOV 2008
  2. Article first published online: 29 OCT 2008
  3. Manuscript Received: 31 JUL 2008

Funded by

  • FFG
  • Province of Styria

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Keywords:

  • amines;
  • asymmetric catalysis;
  • biocatalysis;
  • cascade reactions;
  • reductive amination
Thumbnail image of graphical abstract

All for one: A combination of three biocatalysts (ω-transaminase, alanine dehydrogenase, and an enzyme such as formate dehydrogenase for cofactor recycling) catalyze a cascade to achieve the asymmetric transformation of a ketone into a primary α-chiral unprotected amine through a formal stereoselective reductive amination (see scheme). Only ammonia and the reducing agent (formate) are consumed during this reaction.

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