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Keywords:

  • bacteriocins;
  • biosynthesis;
  • enzymes;
  • natural products;
  • ribosomal peptides
Thumbnail image of graphical abstract

An extended family: The addition of microviridin B (see structure) and trunkamide to the ribosomal peptide biosynthetic family extends the molecular basis of posttranslational modifying reactions to include ω-ester/ω-amide linkage by ATP-grasp ligases (red) and prenylation. The discovery of these novel secondary metabolic reactions may presage the bioengineering of new antimicrobial peptide libraries.