Extending the Biosynthetic Repertoire in Ribosomal Peptide Assembly



original image

An extended family: The addition of microviridin B (see structure) and trunkamide to the ribosomal peptide biosynthetic family extends the molecular basis of posttranslational modifying reactions to include ω-ester/ω-amide linkage by ATP-grasp ligases (red) and prenylation. The discovery of these novel secondary metabolic reactions may presage the bioengineering of new antimicrobial peptide libraries.