Highlight

Extending the Biosynthetic Repertoire in Ribosomal Peptide Assembly

  1. Bradley S. Moore Prof. Dr.

Article first published online: 8 OCT 2008

DOI: 10.1002/anie.200803868

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 47, Issue 49, pages 9386–9388, November 24, 2008

Additional Information

How to Cite

Moore, B. (2008), Extending the Biosynthetic Repertoire in Ribosomal Peptide Assembly. Angewandte Chemie International Edition, 47: 9386–9388. doi: 10.1002/anie.200803868

Author Information

  1. Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0204 (USA), Fax: (+1) 858-534-1305 http://moorelab.ucsd.edu

Publication History

  1. Issue published online: 20 NOV 2008
  2. Article first published online: 8 OCT 2008

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (410K)

Keywords:

  • bacteriocins;
  • biosynthesis;
  • enzymes;
  • natural products;
  • ribosomal peptides

Graphical Abstract

Thumbnail image of graphical abstract

An extended family: The addition of microviridin B (see structure) and trunkamide to the ribosomal peptide biosynthetic family extends the molecular basis of posttranslational modifying reactions to include ω-ester/ω-amide linkage by ATP-grasp ligases (red) and prenylation. The discovery of these novel secondary metabolic reactions may presage the bioengineering of new antimicrobial peptide libraries.

View Full Article (HTML) Get PDF (410K)