The authors gratefully acknowledge generous financial support from the Deutsche Forschungsgemeinschaft.
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Communication
Generation of Highly Enantioenriched Crystalline Products in Reversible Asymmetric Reactions with Racemic or Achiral Catalysts†
Article first published online: 12 DEC 2008
DOI: 10.1002/anie.200803877
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Tsogoeva, Svetlana B., Wei, S., Freund, M. and Mauksch, M. (2009), Generation of Highly Enantioenriched Crystalline Products in Reversible Asymmetric Reactions with Racemic or Achiral Catalysts. Angew. Chem. Int. Ed., 48: 590–594. doi: 10.1002/anie.200803877
- †
Publication History
- Issue published online: 29 DEC 2008
- Article first published online: 12 DEC 2008
- Manuscript Revised: 13 OCT 2008
- Manuscript Received: 6 AUG 2008
Funded by
- Deutsche Forschungsgemeinschaft
Keywords:
- asymmetric amplification;
- chiral resolution;
- chirality;
- crystal growth;
- nucleophilic addition reactions
Backwards is better: By combining forward and backward reaction steps of a reversible chemical process (see scheme) with the physical processes of crystallization, crystal crushing, and dissolution, asymmetric amplification up to 100 % ee can be achieved in the presence of racemic or achiral catalysts starting from a conglomerate of the reaction product 1 with a low enantiomeric excess.