This work was generously supported by the DIUS and Siemens Molecular Imaging (Project No TP/16636)
1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Communication
Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process†
Article first published online: 3 DEC 2008
DOI: 10.1002/anie.200803897
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Bejot, R., Fowler, T., Carroll, L., Boldon, S., Moore, J., Declerck, J. and Gouverneur, V. (2009), Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process. Angewandte Chemie International Edition, 48: 586–589. doi: 10.1002/anie.200803897
- †
Publication History
- Issue published online: 29 DEC 2008
- Article first published online: 3 DEC 2008
- Manuscript Revised: 10 OCT 2008
- Manuscript Received: 7 AUG 2008
Funded by
- DIUS
- Siemens Molecular Imaging. Grant Number: TP/16636
Keywords:
- fluorine;
- positron emission tomography;
- radiopharmaceuticals;
- synthetic methods
Graphical Abstract
Tag team: The fluoro-detagging of fluorous sulfonates by the [18F]fluoride ion was found to be an advantageous strategy for the preparation of various 18F-labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided.