We thank the University of Wisconsin for startup funding and the Analytical Instrument Center (AIC) for NMR support.
Synthesis of Cyclobutenes by Highly Selective Transition-Metal-Catalyzed Ring Expansion of Cyclopropanes†
Article first published online: 10 OCT 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 47, Issue 46, pages 8933–8936, November 3, 2008
How to Cite
Xu, H., Zhang, W., Shu, D., Werness, Jenny B. and Tang, W. (2008), Synthesis of Cyclobutenes by Highly Selective Transition-Metal-Catalyzed Ring Expansion of Cyclopropanes. Angew. Chem. Int. Ed., 47: 8933–8936. doi: 10.1002/anie.200803910
- Issue published online: 28 OCT 2008
- Article first published online: 10 OCT 2008
- Manuscript Received: 7 AUG 2008
- University of Wisconsin
- homogeneous catalysis;
- ring expansion
A highly chemoselective, regioselective, and stereospecific synthesis of polysubstituted cyclobutenes, by catalyst-controlled ring expansion of cyclopropanes via metal carbene intermediates, is reported. Transition-metal catalysts showed profound effects on the reactivity and selectivity of metal carbene intermediates in this ring-expansion reaction.