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Keywords:

  • glutamate;
  • neurotransmitters;
  • photolysis;
  • synthetic methods;
  • two-photon absorption
Thumbnail image of graphical abstract

Open the cage: Symmetrical photoremovable bis-glutamate cages have been designed, synthesized, and characterized that can release a neurotransmitter with unprecedented two-photon efficiencies (see picture), up to 5 GM for BNSF–Glu (BNSF=2,7-bis-{4-nitro-8-[3-(2-propyl)-styryl]}-9,9-bis-[1-(3,6-dioxaheptyl)]-fluorene) at 800 nm, the optimal window both for tissue transparency and classically available laser sources.