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Protein-Functionalized Synthetic Antiferromagnetic Nanoparticles for Biomolecule Detection and Magnetic Manipulation


  • This work was supported by grants from NIH (1U54 CA119367-01, S.S.G.), NSF (ECCS-0801385 and DBI-0551990, S.X.W.), a NIH Pathway to Independence Award (1K99 EB008558-01, A.F.), and a Stanford Graduate Fellowship (W.H.).


Direct protein functionalization provides synthetic antiferromagnetic nanoparticles with high chemical specificity and multifunctionality. These nanoparticle–protein conjugates function as improved magnetic labels for biological detection experiments, and exhibit tunable responses to a small external magnetic field gradient, thus allowing the observation of distinctive single nanoparticle motion.

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