Control of Duplex Formation and Columnar Self-Assembly with Heterogeneous Amide/Urea Macrocycles

Authors

  • Lucile Fischer,

    1. CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 rue René Descartes, 67000 Strasbourg (France), Fax: (+33) 3-8861-0680
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  • Marion Decossas Dr.,

    1. CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 rue René Descartes, 67000 Strasbourg (France), Fax: (+33) 3-8861-0680
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  • Jean-Paul Briand Dr.,

    1. CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 rue René Descartes, 67000 Strasbourg (France), Fax: (+33) 3-8861-0680
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  • Claude Didierjean Dr.,

    1. LCM3B, UMR-CNRS 7036, Groupe Biocristallographie, Université Henri Poincaré, BP 239, 54506 Vandœuvre (France)
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  • Gilles Guichard Dr.

    1. CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 rue René Descartes, 67000 Strasbourg (France), Fax: (+33) 3-8861-0680
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  • This research was supported in part by Centre National de la recherche Scientifique (CNRS), and Agence Nationale pour la Recherche (grant number NT05_4_42848). The authors thank Lionel Allouche and Roland Graff for their assistance with NMR 1H- and DOSY experiments and the “plateforme RIO d'imagerie cellulaire Strasbourg Esplanade” for the use of the TEM.

Abstract

The perfect blend : A new class of self-assembling cyclooligomers with mixed urea/amide backbone is described (see figure). A high level of hierarchical and directional control is achieved: depending on the level of backbone preorganization, columnar or tubular arrangements with either parallel or antiparallel growing modes can be selected.

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