Belizeanolide, a Cytotoxic Macrolide from the Dinoflagellate Prorocentrum belizeanum

Authors

  • José G. Napolitano,

    1. Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Francisco Sánchez 2, 38206 La Laguna, Tenerife (Spain), Fax: (+34) 922-318-571
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  • Manuel Norte Prof.,

    1. Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Francisco Sánchez 2, 38206 La Laguna, Tenerife (Spain), Fax: (+34) 922-318-571
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  • José M. Padrón Dr.,

    1. Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Francisco Sánchez 2, 38206 La Laguna, Tenerife (Spain), Fax: (+34) 922-318-571
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  • José J. Fernández Prof.,

    1. Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Francisco Sánchez 2, 38206 La Laguna, Tenerife (Spain), Fax: (+34) 922-318-571
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  • Antonio Hernández Daranas Dr.

    1. Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Francisco Sánchez 2, 38206 La Laguna, Tenerife (Spain), Fax: (+34) 922-318-571
    2. Departamento de Ingeniería Química y Tecnología Farmacéutica, Universidad de La Laguna, Francisco Sánchez 2, 38071 La Laguna, Tenerife (Spain)
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  • This research work was funded by Grants AGL2005-07924-C04-01 and CTQ2008-06754V04-01/PPQ from MEC, Spain. J.G.N. and J.M.P. acknowledge MEC for a PhD scholarship and a Ramón y Cajal contract, respectively. We thank J. Gavín for helpful discussions related to NMR spectroscopy, J. R. Hernández-Fernaud for assistance with MS, S. Fraga for the P. belizeanum strain, and J. D. Martín for continuous scientific encouragement.

Abstract

original image

An exclusive club: The first member of an unprecedented class of polyunsaturated and polyhydroxylated macrocycle, belizeanolide (see structure), has been isolated from a marine dinoflagellate. The corresponding open form, belizeanolic acid, was also found. Their structures were determined primarily by analysis of NMR spectroscopic data. Both compounds showed significant antiproliferative activities.

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