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Keywords:

  • alkynes;
  • asymmetric catalysis;
  • nucleophilic substitution;
  • propargylic substitution;
  • transition metals
Thumbnail image of graphical abstract

Keen for a share in the glory: Until recently, the title reaction stood in the shadows, its famous sister, catalytic allylic substitution, in the limelight. Catalytic propargylic substitution has now emerged as an efficient transformation that can be catalyzed by a variety of transition metals (see picture). Among the recent developments are copper-catalyzed asymmetric propargylic amination reactions. Nu = nucleophile