Effective Binding and Sensing of Lipopolysaccharide: Combining Complementary Pattern Recognition Receptors


  • This work was supported by the Leverhulme Trust, The Cystic Fibrosis Trust, The Big Lottery, and The Derek Stewart Charitable Trust. We are grateful to Prof. L. J. Yellowlees for the use of equipment and Profs. M. A. Valvano and J. R. W. Govan for Burkholderia strains.


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Nature inspired: A synthetic receptor (see picture) that exploits two zinc(II) ions and four convergent amino hydrogen bonding groups binds lipopolysaccharides (LPSs) almost as strongly as the LPS binding protein. This feature is exploited to electrochemically distinguish LPS from other pathogens in water and in complex biological mixtures. Zn pink, N blue, P orange, O red.