SEARCH

SEARCH BY CITATION

Keywords:

  • atropisomerism;
  • cyclization;
  • hypoestoxide;
  • natural products;
  • total synthesis
Thumbnail image of graphical abstract

The bicycle works: A versatile route to the verticillane family of natural products has been devised, utilizing a strategically rigidified relay ring-closing metathesis reaction. The shape of the bicyclic product was used to stereoselectively control the bisepoxidation reaction towards hypoestoxide, a member of this natural product family.