Communication

A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry†

  1. Nick Mitchell1,
  2. Robert Schlapak2,
  3. Markus Kastner3,
  4. David Armitage Dr.4,
  5. Wojciech Chrzanowski Dr.5,6,
  6. Johannes Riener3,
  7. Peter Hinterdorfer Prof.3,
  8. Andreas Ebner Dr.3,
  9. Stefan Howorka Dr.1,2

Article first published online: 9 DEC 2008

DOI: 10.1002/anie.200804264

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 3, pages 525–527, January 5, 2009

Additional Information

How to Cite

Mitchell, N., Schlapak, R., Kastner, M., Armitage, D., Chrzanowski, W., Riener, J., Hinterdorfer, P., Ebner, A. and Howorka, S. (2009), A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry. Angew. Chem. Int. Ed., 48: 525–527. doi: 10.1002/anie.200804264

Author Information

  1. 1

    Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ (UK), Fax: (+44) 20-7679-7463

  2. 2

    Center for Biomedical Nanotechnology, Upper Austrian Research, Linz, 4020 (Austria)

  3. 3

    Institute for Biophysics, Johannes Kepler University, Linz, 4040 (Austria)

  4. 4

    Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH (UK)

  5. 5

    Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, London, WC1X 8LD (UK)

  6. 6

    Present address: Department of Mechanical Engineering, University of Glasgow, Glasgow, G12 8QQ (UK)

  1. †

    Funded by the Austrian Science Foundation (project N00104-NAN), the European Fund for Regional Development (EFRE), and the government of Upper Austria. N.M. holds a PhD studentship from the Department of Chemistry, UCL and a scholarship from the Postgraduate School, UCL. We thank Hugh Martin for the preparation of Figure 1 a and 1c.

Publication History

  1. Issue published online: 29 DEC 2008
  2. Article first published online: 9 DEC 2008
  3. Manuscript Received: 28 AUG 2008

Funded by

  • Austrian Science Foundation. Grant Number: N00104-NAN
  • European Fund for Regional Development
  • Upper Austria
Corrected by:

Corrigendum: A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry

Vol. 48, Issue 48, 9016, Article first published online: 11 NOV 2009

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Keywords:

  • DNA structures;
  • nano-biotechnology;
  • self-assembly;
  • supramolecular chemistry;
  • thin films
Thumbnail image of graphical abstract

Many legs make light work: Tetrahedra are constructed with edges of double-stranded DNA and vertices tagged with biotin or disulfide units (see picture). They can act as supramolecular scaffolds to combine different chemical groups at defined nanoscale distances and with tunable stoichiometries. The disulfide groups bind to gold surfaces with high affinity, which leaves the biotin unit poised to capture streptavidin.

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