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Keywords:

  • DNA structures;
  • nano-biotechnology;
  • self-assembly;
  • supramolecular chemistry;
  • thin films
Thumbnail image of graphical abstract

Many legs make light work: Tetrahedra are constructed with edges of double-stranded DNA and vertices tagged with biotin or disulfide units (see picture). They can act as supramolecular scaffolds to combine different chemical groups at defined nanoscale distances and with tunable stoichiometries. The disulfide groups bind to gold surfaces with high affinity, which leaves the biotin unit poised to capture streptavidin.