We acknowledge generous funding from the Max-Planck-Society and the DFG SPP 1179 (Organocatalysis). We also thank H. W. Klein and W. Joppek for technical assistance.
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Communication
Characterization of Key Intermediates in a Complex Organocatalytic Cascade Reaction Using Mass Spectrometry†
Article first published online: 15 JAN 2009
DOI: 10.1002/anie.200804353
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Schrader, W., Handayani, P., Zhou, J. and List, B. (2009), Characterization of Key Intermediates in a Complex Organocatalytic Cascade Reaction Using Mass Spectrometry. Angew. Chem. Int. Ed., 48: 1463–1466. doi: 10.1002/anie.200804353
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Publication History
- Issue published online: 30 JAN 2009
- Article first published online: 15 JAN 2009
- Manuscript Received: 3 SEP 2008
Funded by
- Max-Planck-Society
- DFG. Grant Number: SPP 1179
Keywords:
- cascade reactions;
- complexe reactions;
- electrospray mass spectrometry;
- iminium catalysis;
- organocatalysis
Abstract
Chemical scrabble: Mechanistic studies of complex organocatalytic cascade reactions are challenging owing to the presence of many species involved. Electrospray ionization mass spectrometry provides details about a one-pot quadruple organocatalytic cascade reaction, and allows detailed characterization of the reaction and its key intermediates.