We thank the Swiss Federal Institute of Technology (ETH) Zurich and Merck Sharp and Dohme for financial support.
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Communication
5-(Pyrrolidin-2-yl)tetrazole-Catalyzed Aldol and Mannich Reactions: Acceleration and Lower Catalyst Loading in a Continuous-Flow Reactor†
Article first published online: 13 MAR 2009
DOI: 10.1002/anie.200804407
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Odedra, A. and Seeberger, Peter H. (2009), 5-(Pyrrolidin-2-yl)tetrazole-Catalyzed Aldol and Mannich Reactions: Acceleration and Lower Catalyst Loading in a Continuous-Flow Reactor. Angew. Chem. Int. Ed., 48: 2699–2702. doi: 10.1002/anie.200804407
- †
Publication History
- Issue published online: 24 MAR 2009
- Article first published online: 13 MAR 2009
- Manuscript Received: 6 SEP 2008
Funded by
- Swiss Federal Institute of Technology (ETH) Zurich
- Merck Sharp and Dohme
Keywords:
- aldol reaction;
- asymmetric catalysis;
- continuous-flow reactors;
- microreactors;
- organocatalysis
Abstract
Continuous organocatalysis: Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5–10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 °C with reaction times ranging from 10 to 30 min.