We thank the University of Geneva and the Swiss NSF for financial support.
Amplifier-Mediated Activation of Cell-Penetrating Peptides with Steroids: Multifunctional Anion Transporters for Fluorogenic Cholesterol Sensing in Eggs and Blood†
Article first published online: 3 DEC 2008
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 2, pages 325–328, January 2, 2009
How to Cite
Butterfield, Sara M., Miyatake, T. and Matile, S. (2009), Amplifier-Mediated Activation of Cell-Penetrating Peptides with Steroids: Multifunctional Anion Transporters for Fluorogenic Cholesterol Sensing in Eggs and Blood. Angew. Chem. Int. Ed., 48: 325–328. doi: 10.1002/anie.200804422
- Issue published online: 22 DEC 2008
- Article first published online: 3 DEC 2008
- Manuscript Received: 8 SEP 2008
- University of Geneva
- Swiss NSF
- ion transport;
Off-the-shelf, prêt-à-porter multianalyte sensing systems are based on the ability of cell-penetrating peptides (CPPs; see picture, blue) to mediate the export of hydrophilic anions (yellowgreen) from lipid bilayer vesicles (gray). Covalent capture of hydrophobic analytes (black) with hydrophilic anions (red) produces amphiphilic anions that can activate CPPs.