This research was supported financially by Saltigo GmbH, the Deutsche Forschungsgemeinschaft (DFG, Emmy-Noether program), the Fonds der Chemischen Industrie (FCI), and the Deutsche Bundesstiftung Umwelt (DBU). We thank Prof. H.-G. Schmalz for generous support.
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Communication
Domino Iron Catalysis: Direct Aryl–Alkyl Cross-Coupling†
Article first published online: 9 DEC 2008
DOI: 10.1002/anie.200804434
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Czaplik, W., Mayer, M. and Jacobi von Wangelin, A. (2009), Domino Iron Catalysis: Direct Aryl–Alkyl Cross-Coupling. Angew. Chem. Int. Ed., 48: 607–610. doi: 10.1002/anie.200804434
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Publication History
- Issue published online: 29 DEC 2008
- Article first published online: 9 DEC 2008
- Manuscript Received: 8 SEP 2008
Funded by
- Saltigo GmbH
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie (FCI)
- Deutsche Bundesstiftung Umwelt (DBU)
Keywords:
- cross-coupling;
- domino reactions;
- Grignard reactions;
- iron;
- sustainable chemistry
Striking while the iron is hot: Cheap FeCl3 serves as the precatalyst for the direct cross-coupling of aryl and alkyl halides that is based on the sequence of Grignard formation and subsequent cross-coupling. This one-pot reaction obviates preformation of hazardous Grignard compounds and limits the amount of reactive organomagnesium intermediates to low quasi-stationary concentrations. TMEDA=N,N,N′,N′-tetramethylethylenediamine.