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Domino Iron Catalysis: Direct Aryl–Alkyl Cross-Coupling


  • This research was supported financially by Saltigo GmbH, the Deutsche Forschungsgemeinschaft (DFG, Emmy-Noether program), the Fonds der Chemischen Industrie (FCI), and the Deutsche Bundesstiftung Umwelt (DBU). We thank Prof. H.-G. Schmalz for generous support.


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Striking while the iron is hot: Cheap FeCl3 serves as the precatalyst for the direct cross-coupling of aryl and alkyl halides that is based on the sequence of Grignard formation and subsequent cross-coupling. This one-pot reaction obviates preformation of hazardous Grignard compounds and limits the amount of reactive organomagnesium intermediates to low quasi-stationary concentrations. TMEDA=N,N,N′,N′-tetramethylethylenediamine.