We thank the Fonds der Chemischen Industrie, the Deutsche Forschungsgesellschaft (DFG), and SFB 749 for financial support.
Copper-Catalyzed Asymmetric Michael Addition of Magnesium, Zinc, and Aluminum Organometallic Reagents: Efficient Synthesis of Chiral Molecules†
Article first published online: 29 DEC 2008
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 4, pages 645–648, January 12, 2009
How to Cite
Thaler, T. and Knochel, P. (2009), Copper-Catalyzed Asymmetric Michael Addition of Magnesium, Zinc, and Aluminum Organometallic Reagents: Efficient Synthesis of Chiral Molecules. Angew. Chem. Int. Ed., 48: 645–648. doi: 10.1002/anie.200804446
- Issue published online: 5 JAN 2009
- Article first published online: 29 DEC 2008
- Fonds der Chemischen Industrie
- Deutsche Forschungsgesellschaft (DFG)
- asymmetric catalysis;
- homogeneous catalysis;
- Michael addition
Choosing the right metal for the job: A broad range of asymmetric conjugate addition reactions are catalyzed efficiently by copper complexes, provided the appropriate organometallic reagent is used. With aluminum reagents, for example, quaternary stereogenic centers with functionalized aryl substituents can be generated with high enantioselectivity (see scheme).