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We thank EPSRC and the Wellcome Trust for funding.
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Communication
Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds†
Article first published online: 17 NOV 2008
DOI: 10.1002/anie.200804486
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Morton, D., Leach, S., Cordier, C., Warriner, S. and Nelson, A. (2009), Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds. Angewandte Chemie International Edition, 48: 104–109. doi: 10.1002/anie.200804486
- †
Publication History
- Issue published online: 18 DEC 2008
- Article first published online: 17 NOV 2008
- Manuscript Received: 11 SEP 2008
Funded by
- EPSRC
- Wellcome Trust
Keywords:
- cascade chemistry;
- diversity-oriented synthesis;
- metathesis;
- molecular scaffolds;
- natural products
Graphical Abstract
Seeking scaffold diversity: A synthetic approach for the combinatorial variation of the scaffolds of small molecules is described. Using just six basic reaction types, compounds with 84 distinct scaffolds were prepared. The compounds had many natural-product-like structural features including rich stereochemistry, heterocyclic and unsaturated ring systems, and dense functionalization.