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SLEEPLESS-ness and Insomnia in Fruit Flies†

  1. Jennifer B. Treweek1,2,
  2. Amira Y. Moreno1,2,
  3. Kim D. Janda Prof. Dr.1,2

Article first published online: 15 DEC 2008

DOI: 10.1002/anie.200804552

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 3, pages 438–440, January 5, 2009

Additional Information

How to Cite

Treweek, Jennifer B., Moreno, Amira Y. and Janda, Kim D. (2009), SLEEPLESS-ness and Insomnia in Fruit Flies. Angew. Chem. Int. Ed., 48: 438–440. doi: 10.1002/anie.200804552

Author Information

  1. 1

    Department of Chemistry and Immunology, Skaggs Institute for Chemical Biology

  2. 2

    Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road (BCC582), CA 92037 (USA), Fax: (+1) 858-784-2595 http://www.scripps.edu/chem/janda/

  1. †

    We acknowledge The Skaggs Institute for Chemical Biology, the Ruth L. Kirschstein National Research Service Award, and the Novartis Graduate Fellowship in Organic Chemistry for Women and Minorities.

Publication History

  1. Issue published online: 29 DEC 2008
  2. Article first published online: 15 DEC 2008

Funded by

  • The Skaggs Institute for Chemical Biology
  • Ruth L. Kirschstein National Research Service Award,

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Keywords:

  • genetics;
  • ion channels;
  • mutagenesis;
  • sleep
Thumbnail image of graphical abstract

Lord of the flies: A gene, sleepless, has been identified in Drosophila that when mutagenized imparted an extreme short-sleeping phenotype. SLEEPLESS expression is independent of the circadian clock and was found to participate in the homeostatic regulation of sleep. Namely, SLEEPLESS appears to be a signaling molecule that couples sleep drive to changes in membrane excitability (see picture).

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