Communication

A Selective Inhibitor Gal-PUGNAc of Human Lysosomal β-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells†

  1. Keith A. Stubbs Dr.1,2,
  2. Matthew S. Macauley1,
  3. David J. Vocadlo Prof.1

Article first published online: 7 JAN 2009

DOI: 10.1002/anie.200804583

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 7, pages 1300–1303, February 2, 2009

Additional Information

How to Cite

Stubbs, Keith A., Macauley, Matthew S. and Vocadlo, David J. (2009), A Selective Inhibitor Gal-PUGNAc of Human Lysosomal β-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells. Angew. Chem. Int. Ed., 48: 1300–1303. doi: 10.1002/anie.200804583

Author Information

  1. 1

    Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6 (Canada), Fax: (+1) 604-291-3765

  2. 2

    Current address: Chemistry M313, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009 (Australia), Fax: (+618) 6488-1005

  1. †

    K.A.S. and M.S.M. contributed equally to this work. We thank Don Mahuran and Michael Tropak for their generous gift of human HEXA and HEXB, Rosemary Cornell for the HPTLC plates, and Cara-Lynne Schengrund for useful discussions on the use of SK-N-SH cells and HPTLC of gangliosides. This work was supported by a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC). D.J.V. is a scholar of the Michael Smith Foundation of Health Research (MSFHR) and a Tier II Canada Research Chair in Chemical Glycobiology. K.A.S. is supported by a Discovery project grant from the Australian Research Council. M.S.M. is a recipient of a senior scholarship from the NSERC and MSFHR.

Publication History

  1. Issue published online: 28 JAN 2009
  2. Article first published online: 7 JAN 2009
  3. Manuscript Received: 17 SEP 2008

Funded by

  • Natural Sciences and Engineering Research Council of Canada (NSERC)
  • Michael Smith Foundation of Health Research (MSFHR)
  • Australian Research Council

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